Why Partner with SimBioSys?
Understanding why or why not a patient responds to a specific therapy remains a challenge and assessing the heterogeneity within tumors remains critical for the entire development lifecycle.
Current techniques do not account for the multiple scales and mechanisms of cancer.
SimBioSys TumorScope platform enables drug developers to capture tumor biology and heterogeneity to predict responses to therapy, providing more comprehensive insights, signatures and biomarkers than ex vivo or in vitro techniques alone.
Predict Response to Therapy
Predict endpoints such as objective response rate to therapy in silico and assess the incremental benefit of experimental agents
Novel Insights & Biomarkers
Combine all major hallmarks of cancer variation for a comprehensive approach to patient stratification including drug delivery, drug sensitivity, tumor metabolism and spatial heterogeneity
SimBioSys’ multidimensional approach bridges the gap between preclinical techniques and humans
Enhancing Translational Research & Drug Development
Proprietary models & services that can be utilized individually or as a platform
Transforming existing -omics data with proprietary systems biology techniques to capture metabolic variation in tumors to predict, prognosticate and stratify patient response
Spatially resolved tumor analysis uncovering tumor metabolic and biophysical diversity
In silico modeling in patient tumors to assess and optimize the impact of drug delivery on tumor response
Proprietary image segmentation models for various imaging modalities and pathology slides to capture tumor and tumor microenvironment
Novel Signatures for Immunotherapies beyond PD-1 & PD-L1 capturing insights on spatial metabolism of tumor and lymphyocytes
Discovery of differentiated and multi-scale biomarkers to add actionable insights
Novel image based signatures to predict response at a voxel level going beyond traditional metrics
Trial design, analysis, and expansion; including patient selection, synthetic control arms, experimental vs. SoC benefit assessment
Test multiple drug scenarios in thousands of patient tumors, capturing morphology, microenvironment, spatial metabolism at a fraction of the time/cost of traditional studies
Supporting All Stages of Drug Development
SimBioSys is supporting the fight against cancer from idea to commercialization. Its ability to model, simulate and predict tumor response to therapies makes it an essential tool for pharmaceutical developers at every stage of the development cycle
- Genome-to-Phenome Insights
- Multiscale data analysis and visualization
- Customizable, Cloud-Scaling Computational Biology Workflows
- Contextualizing Novel Data
Regulated Clinical Tool
- In Silico Drug Testing
- Clinical Trial Selection
- Synthetic Control Arm Design
- Novel Biomarker Development