What are the others publishing about us...

• Feb 2010; iSGTW (International Science Grid This Week); in Issue 161: iSGTW 10 February 2010 there was an article by Danielle Venton with the title: "Playstation goes from games to grid", writing about SimBioSys' eHiTS Lightning software application:

  ...The PS3 is the latest piece of hardware to get on the grid. A mini-cluster of PS3s in Ireland is running software which can screen for new and potentially life-saving drugs...

  Click here to see the article online, or see it on our site.
  
  
• May 25., 2009, Chemical & Engineering News, Volume 87, Number 21, p. 40, in the "Digital Briefs" of the "Science and Technology" section Lauren K. Wolf wrote:
  

  PlayStation Revs Up Drug Discovery

  Toronto-based firm SimBioSys recently launched the newest version of its molecular docking and virtual screening software, eHiTS 2009. This drug discovery tool boasts an improved scoring function trained on thousands of up-to-date Protein Data Bank structures and is tuned for 500 new protein classes...
  ...This package combines the 2009 eHiTS software with IBM's Cell/B.E. chip multiprocessor, found in the Sony PlayStation 3, to achieve a 10-fold increase in computational speed...

  Click here to see the article online, or see it on our site.
  
  
• Nov 24., 2008, Chemical & Engineering News, Volume 86, Number 47, p. 44, in the "Digital Briefs" Lauren K. Wolf wrote:
  

  ARChem (Automated Retrosynthetic Chemistry) Route Designer is a new software tool that aids synthetic chemists in planning organic synthesis. The software employs reaction databases such as CrossFire and Accelrys' Methods of Organic Synthesis (MOS), starting material catalogs such as those from Aldrich and Lancaster, and optional user input to aid in viable synthetic route design. With chemical perception algorithms, ARChem identifies reaction cores and generalizes reaction rules to make a retrosynthetic "solution tree" for a user's target molecule...

  Click here to see the article online, or see it on our site.
  
  
• Oct 1., 2008, Chemistry World, Sept 2010 issue, Software Review section: "Finding actives with diverse chemical scaffolds, but similar surface properties: eHiTS and LASSO", by Susan Boyd:
  
  "eHiTS is a bit different from most, in that it combines truly exhaustive, fast docking with a
  rather neat scoring function, based on projected interaction surface points (ISPs)...These surface points should better represent the interactions...this has been supported by
  several reported validation tests (Simbiosys: by Merck and others). This allows it to handle the more subtle interactions, such as those involving π-systems and metals....
  
  LASSO is the ligand-based equivalent of eHiTS, using the interaction surface points as fuzzy 3D descriptors to identify similar compounds to the input query using a neural network algorithm.... Again the speed here is worthy of note.... 8 million compounds can be searched in only a couple of minutes"
  
  Click here to see the article online, or see it on our site
  
  
• July 14, 2008, BioIT World: " PlayStation Cell Speeds Docking Programs", by Mike May:
  

  SimBioSys with IBM, Sony to speed drug discovery.

  "...the Cell Broadband Engine, which was developed jointly by IBM, Sony, and Toshiba. Even though this processor powers Sony’s Playstation PS3, the Cell goes beyond games. .. for docking simulations .. the Cell turned out to be just the right tool for SimBioSys."
  
  Click here to see the article online, click here to see our blog posting about it.
  
• May 29., 2008, BioIT World: "GTA4: Enabler of Life Sciences Research?", by Salvatore Salamone:
  

  Life sciences researchers should be thrilled, because the success of the video games is enabling their research, and so is SimBioSys, says  Salvatore Salamone from BIO-IT world, read the full story here:

  Check out the article here, or see it on our site

• Feb 1., 2008, BioIT World (Feb) cover story: "The Search for Unusual Suspects", by Vicki Glaser:
  

  This article discusses the use of scaffold hopping tools, including LASSO:

  SimBioSys designed eHiTS LASSO (electronic High Throughput Screening Ligand Activity by Surface Similarity Order) as a tool for virtual ligand screening. It generates an interacting surface point type molecular descriptor from the 3D structure of a ligand that is conformation independent and, together with a neural network machine learning technique, screens molecular databases at a rate of 1 million structures in less than 1 minute.

  Check out the article here, or see it on our site

• Sept 10., 2007, Chemical & Engineering News, Volume 85, Number 37, p. 38, in the "Digital Briefs" Stephen M. Trzaska wrote:
  

  CheVi

  CheVi v.6.1 is a chemical visualizing package designed to give insight into how ligands and receptors interact. The user can visualize receptor binding site characteristics, in which the color-coded receptor surface dramatically displays the characteristics of the binding site, and ligand properties, in which the surface of the ligand can also be visualized to show the chemical characteristics of the ligand. The software also visualizes key receptor-ligand interactions, whereby showing strong interactions between ligand and receptor with color-coded dashed lines can give valuable information on how and why a ligand docks in a particular position. CheVi has a Web-based user interface with 3-D capabilities and has an export capability for high-resolution, publication-quality images. The software is currently available on Linux and will soon be available on most other platforms. Simulated Biomolecular Systems, www.simbiosys.com

  see the Article or see it on our site.
  
  
• Jan., 2006, Bioorganic & Medicinal Chemistry Letters vol.16, Issue 6, March 15 2006, pages 1610-1615:
  

  Brequinar derivatives and species-specific drug design
  for dihydroorotate dehydrogenase
  

  "Docking with eHiTS^� produced trends in scores that were largely in agreement with experimentally determined measures of inhibition, especially for atovaquone and brequinar. The rms deviation in position for these docked compounds as compared to their crystal structures was less than 0.5 A ˚ . This agreement permits a degree of confidence in the predictions of the docking algorithm."

  
  by  Darrell E. Hurt(a), Amanda E. Suttona(a) and Jon Clardy(b)
  (a) Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA
  (b) Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA
  see the Article

• Jun., 2005, J. Am. Chem. Soc.; (Computer Software Review):
  

  eHiTS

  "... Overall, eHiTS is an easy to use flexible docking program that may appeal to both academic and industrial chemists who want to perform docking studies rapidly on individual ligands and on virtual databases of ligands. The most appealing aspect of this software is its ease of use. Other nice features include the customizable scoring function that can be optimized for specific receptor complexes, and the speed and accuracy of docking ..."

  by Prof. S. M. Kerwin, University of Texas, Division of Medicinal Chemistry
  see the Article

• Nov. 2003 , Issue 67, Elemental Discoveries:
  

  CAESA

  "...Industrial chemists and pharmaceutical scientists will love CAESA - it saves them time and effort! It allows targets to be assessed and organised according to complexity of synthesis as well as helping in the search for more efficient routes to a compound..."

  Read David Bradley's review of CAESA at his sciencebase chemistry news website

• May/June 2003, Issue 70, page 67, Scientific Computing World:
  

  CLiDE

  "...It is a fantastic program in concept, and I can see it being developed much further for large pharmaceutical company databases and abstracting services..."

  
  At last! Recognition for chemists
  by David Bradley
  Scientific Computing World, May/June 2003, Issue 70, page 67

• Nov. 15, 2002: Genetic Engeneering News:

SPROUT and eHiTS

"... New approaches to save time, material and money... discovery with  SimBioSys's new rational drug design methods: SPROUT and eHiTS"


Advances in Rational Drug Design Methods by Shannon Simmons

• July1, 2001 Toronto Star, @ Business section:
  

  tools from SimBioSys, Inc.

  " ... biotech companies are eager for new technologies that can speed up the process of drug discovery... SimBioSys Inc. of Toronto develops just those kinds of tools. "

  
  Will biotech boom ? by Rachael Ross